Market Snapshot

Market Overview

The Global RNA-Sequencing & Analysis (RNA-seq) Market size was estimated at USD 2.8 billion in 2022 and is projected to reach USD 8.7 billion in 2030 at a CAGR of 17.7% during the forecast period 2023-2030.

RNA-seq is a widely used technique that provides comprehensive insights into the genomic makeup of an organism or cell. This technique is used in both traditional and non-traditional applications, such as identifying gene expression patterns, detecting mutations, and studying epigenetic modifications. The demand for better sequencing-based diagnostics has led to the development of novel sequencing technologies that can provide more accurate and reliable results. High-throughput sequencers and portable units are two examples of such technologies that have become increasingly popular due to their ability to generate large amounts of data quickly and efficiently.

Next-generation sequencing (NGS) technology is a relatively new technology that has gained immense popularity since its launch due to its ability to provide advanced and comprehensive genetic insights. NGS technology is widely used in both traditional and non-traditional applications, such as in research, clinical diagnostics, and personalized medicine, to analyze DNA and RNA sequences. The growing demand for enhanced sequencing-based diagnostics has led to the development of new sequencing technologies that offer improved accuracy, speed, and cost-effectiveness.

RNA sequencing is a technique used to determine the sequence of nucleotides in RNA molecules, which can provide valuable information about the virus's genetic makeup. Single-cell RNA sequencing, stranded RNA sequencing, and ultra-low input RNA sequencing are different methods used to study the virus's features and epidemiology across diverse countries. Single-cell RNA sequencing allows researchers to study individual cells and their gene expression patterns, while stranded RNA sequencing can determine the directionality of RNA molecules. Ultra-low input RNA sequencing is used when only a small amount of RNA is available for analysis.

Delvens Industry Expert's Standpoint

Next-generation sequencing (NGS) is a high-throughput DNA sequencing technology that has revolutionized the field of genomics. Paired-end (PE) sequencing is a type of NGS that allows for the simultaneous sequencing of both ends of DNA fragments in a library. This technique produces twice as many reads as single-end sequencing, which only sequences one end of the DNA fragment. The forward and reverse reads produced by PE sequencing are aligned as reading pairs, which improves the accuracy of read alignment and enables the detection of insertions and deletions (indels) in the DNA sequence. Indels are important genetic variations that can cause diseases or affect an individual's response to drugs. The ability to detect indels is not achievable with single-read data, which makes PE sequencing a more powerful tool for genomic research. The paired-end strategy is the most modern and well-liked technique among researchers because of its ability to produce high-quality sequencing data and detect genetic variations that are not detectable by other sequencing methods.

Market Portfolio

Key Findings

• On the basis of product and services, these are the products that are used to prepare the RNA samples for sequencing. RNA samples need to be extracted from the cells or tissues and then purified before they can be sequenced. Sample preparation products include kits, reagents, and instruments that are used for RNA extraction, purification, and quality control. services that are offered by sequencing companies or core facilities. Sequencing services include sample processing, library preparation, sequencing, and data analysis. These services are useful for researchers who do not have access to sequencing instruments or who do not have the expertise to perform sequencing themselves. RNA sequencing generates large amounts of data that need to be processed, analyzed, and stored. Data analysis includes quality control, alignment, quantification, and differential expression analysis.
   
• On the basis of technology, Sequencing by Synthesis is a method of DNA sequencing that involves the use of fluorescently labeled nucleotides to identify the sequence of the DNA strand. This method is commonly used in next-generation sequencing (NGS) technologies. Ion Semiconductor Sequencing is a type of NGS technology that uses a semiconductor chip to detect changes in pH caused by the release of hydrogen ions during DNA synthesis. This method is known for its speed and low cost. Single-molecule Real-time Sequencing is another NGS technology that uses a process called zero-mode waveguides to observe the synthesis of DNA in real-time. This method is known for its ability to detect modifications to DNA, such as methylation. Nanopore Sequencing is a third type of NGS technology that uses a nanopore to detect changes in electrical current as DNA strands pass through the pore. This method is known for its ability to sequence long DNA fragments and detect modifications to DNA.
   
• On the basis of Application, Expression Profiling Analysis refers to the process of measuring the expression levels of genes in a given sample. This is done by sequencing the RNA molecules present in the sample and analyzing the resulting data to determine which genes are being transcribed and at what levels. Small RNA Sequencing is a specialized type of RNA sequencing that focuses on the small RNA molecules present in a sample. These molecules are typically less than 200 nucleotides in length and play important roles in gene regulation and other cellular processes. De Novo Transcriptome Assembly is the process of reconstructing the complete set of RNA transcripts present in a sample, without the need for a reference genome. This is done by assembling short RNA sequencing reads into longer contiguous sequences, which can then be annotated and analyzed.
   
• The market is also divided into various regions such as North America, Europe, Asia-Pacific, South America, and Middle East and Africa. North America dominating the NGS-based RNA-sequencing market due to the increasing initiatives and funds from the government for genomics research, growing occurrences of chronic diseases, adoption of RNA-Seq products.

Regional Analysis

North America to Dominate the Market

• North America dominating the NGS-based RNA-sequencing market due to the increasing initiatives and funds from the government for genomics research.
   
• Asia-Pacific is expected to grow at the highest growth rate in the forecast period of 2022 to 2029 due to the increasing levels of investment for research activities and occurrence of better health facilities.